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Compounds Levels of metabolites of DEHP, a phthalate that acts as an anti-androgen, were associated with breast cancer specific mortality in a manner that was moderated by body weight (body mass index or BMI). For women with BMI scores in the normal or lower weight ranges, higher DEHP metabolite levels were associate with higher mortality rates. Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and Cancer: The National Toxicology Program and U.S. Environmental Protection Agency report that DEHP is reasonably to be anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity of animal studies. DEHP is widespread in the environment and detected regularly in human body fluids.

Dehp cancer

Any substance that can cause cancer or 2 Mar 2018 DEHP or MEHP treatment also induced colon cancer cell migration and epithelial -mesenchymal transformation. Elevated stemness-related 30 Sep 2020 The study found that the most harmful phthalate, DEHP, was found between the range of Possible link to breast cancer, obesity, diabetes. DEHP-free devices available. Softness is essential to many medical devices. To make the devices soft, a plasticiser is needed.

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The National Toxicology Program (NTP) says that DEHP “is reasonably anticipated to be a human carcinogen.” Another phthalate, diisononyl phthalate (DINP) has been linked to cancer in rats and mice. The California Office of Environmental Health Hazard Assessment includes DINP on their list of chemicals known to cause cancer. DEHP has been demonstrated to cause developmental toxicity, such as birth defects, in rats and mice from oral exposure. Reproductive effects, such as decreased fertility, proportion of pups born alive, and testicular weights and tubular atrophy, have also been noted from oral exposure to DEHP in animals.

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Exposure to DEHP may increase the risk of cancer, and may also harm the male reproductive system. Exposure to DEHP during pregnancy may affect the development of the child. No studies have evaluated the potential for DEHP to cause cancer in humans. Eating high doses of DEHP for a long time resulted in liver cancer in rats and mice.

We cultured human endometiral cancer cell lines (ECC-1) and then incubated them for 48 h with 50 μM of The exact mechanism(s) by which peroxisomal proliferating agents such as DEHP induce hepatic cancer in rodents are not precisely known, but may be related to the modulation of peroxisomal β oxidation, the PPAR α receptor, gap-junctional intercellular communication, and replicative DNA synthesis (Isenberg et al., 2000). DEHP also causes tumours in the testis and white blood cells in rodents but the relevance of these effects for humans is not known. Adverse effects are also seen in the liver of rats and mice, including liver cancer, but studies have indicated that the mechanism by which phthalates cause liver damage is not relevant for humans. (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisodecyl phthalate (DIDP), di-n-octyl phthal-ate (DnOP), and benzyl butyl phthalate (BBP or BzBP).
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PVC-plaster. DEHP har i många studier cancer. Vid förbränning bildar också väteklorid som bidrar till försurningen.

No studies have evaluated the potential for DEHP to cause cancer in humans, while exposure to high doses of DEHP for a long period of time resulted in liver cancer in rats and mice. In most animal studies, the exposure amounts to DEHP of the animals were much higher than that in the environment. A bout a decade ago, consumer plastics manufacturers began to replace a chemical known as DEHP—a probable human carcinogen, according to the EPA—from their products. The growing consensus was DEHP has been demonstrated to cause developmental toxicity, such as birth defects, in rats and mice from oral exposure.
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When DEHP is released to water, it dissolves very slowly into underground water or surface waters that contact it. It takes many years before DEHP in buried or discarded materials disappears from the environment. BBP, DBP and bis(2-ethylhexyl) phthalate (DEHP) have been shown in laboratory studies to increase growth of human breast cancer cells and decrease the efficacy of tamoxifen, a drug commonly used to treat breast cancer.

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2. Conclusion. The Panel concludes that the evidence is sufficient to establish the carcinogenicity of DEHP for rats and mice.