Draper Secures FDA Contract to Develop Acoustic Separation

Clinical applications of acoustophoresis in blood based

AU - Cushing, Kevin. AU - Nilsson, Johan Keywords acoustophoresis, cell separation, clinical, microfluidics, lab-on-a-chip Introduction Acoustic forces have been used for decades to manipulate particulate matter, although the major efforts have targeted larger chamber and batch-processing systems. 1 These devices mainly used the acoustic force to agglomerate particles into larger clusters, which eventually sedimented and clarified Microfluidic, Label-Free Enrichment of Prostate Cancer Cells in Blood Based on Acoustophoresis | Analytical Chemistry Circulating tumor cells (CTC) are shed in peripheral blood at advanced metastatic stages of solid cancers. Surface-marker-based detection of CTC predicts recurrence and survival in colorectal, breast, and prostate cancer. BAW acoustophoresis has formerly focused on cell and particle handling, whereas here we determine the various abilities of this method for the field of droplet microfluidics. In silicon microdevices, water-in-oil droplets of 200 μm size were generated for a set of unit operations including droplet fusion, focusing, sorting and medium exchange around 0.5-1 MHz acoustic frequency.

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The inertial microfluidics can be used for particle manipulation in a wide range of flow rates by tuning geometry and fluid6,8,9. The acoustophoresis is also a useful technique for rapid and controlled manipulation of bioparticles without affecting their viability6,10– 14. Acoustophoresis: the art of combining acoustics and microfluidics The manipulation of particles is an essential feature of Lab-on-a-chip (LOC) devices. LOC-systems provide a platform where biochemical assays can be miniaturized, integrated and automated in a simple, portable, fast and cost-efficient way.

Acoustic forces are utilized to separate particles based on their size and density. The method is shown to be suitable for both biological and nonbiological suspended particles. The microfluidic separation chips were fabricated using TY - JOUR.

ACOUSTOPHORESIS - Dissertations.se

The inertial microfluidics can be used for particle manipulation in a wide range of flow rates by tuning geometry and fluid6,8,9. The acoustophoresis is also a useful technique for rapid and controlled manipulation of bioparticles without affecting their viability6,10– 14.

Lund University Cancer Center Distinguished Seminar

Metadata The ‘Novel Cell Sorting and Separation Market: Focus on Acoustophoresis, Buoyancy, Dielectrophoresis, Magnetophoretics, Microfluidics, Optoelectronics, Traceless Affinity, and Other Technologies, 2019-2030’ report features an extensive study of the current landscape and future outlook of the growing market for novel cell sorting and separation technologies (beyond conventional methods). Microscale acoustofluidics defines the use of ultrasonic waves onto a fluid inside a microchannel.

Acoustophoresis, the ability to acoustically manipulate particles and cells inside a microfluidic channel, is a critical enabling technology for cell-sorting applications. However, one of the major impediments for routine use of acoustophoresis at clinical laboratory has been the reliance on the inherent physical properties of cells for separation.
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Acoustophoresis enables the label-free separation of functionally different subsets of cultured bone marrow stromal cells Acoustofluidic Blood Component Sample Preparation and Processing in Medical Applications, in Applications of Microfluidics Systems in Biology and Medicine; Surface acoustic wave (SAW) acoustophoresis: now and beyond microfluidics) and active techniques (e.g., acoustophoresis)6.

In this thesis, a microfluidic approach was chosen to However, fluid exchange in droplet microfluidics with high particle recovery is still a major bottleneck. On-chip background dilution in droplets with high particle recovery using acoustophoresis: Biomicrofluidics: Vol 13, No 6 Droplet microfluidics has emerged as a prospering field for lab-on-a-chip devices, where droplets serve as liquid vessels e.g. for biochemical reagents.
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Droplet microfluidics for single cell and nucleic acid - DiVA

However, to date, there is no clinical means available to separate, concentrate and recombine those components directly from the breast milk of the mother. In this thesis, a microfluidic approach was chosen to However, fluid exchange in droplet microfluidics with high particle recovery is still a major bottleneck. On-chip background dilution in droplets with high particle recovery using acoustophoresis: Biomicrofluidics: Vol 13, No 6 Droplet microfluidics has emerged as a prospering field for lab-on-a-chip devices, where droplets serve as liquid vessels e.g.